The NTP has issued its final monograph on the carcinogenicity of antinomy trioxide, a chemical that poses a potential concern to public health, particularly via occupational exposure. Malignant lung tumours in rats and mice of both sexes and tumours at several other tissue sites (adrenal gland in female rats, skin in male mice, and lymphatic system in female mice) were seen following long-term inhalation exposure. Human cancer studies revealed that antinomy‑exposed smelter workers had an elevated mortality from lung cancer (however, this increased risk may have been due to concurrent exposure to other lung carcinogens). In cultured cells, treatment with antinomy trioxide results in oxidative stress (and consequently damage), inhibition of DNA repair and of cell differentiation, indicative of potential carcinogenicity. The NTP concluded that there is “sufficient evidence” to recommend that antinomy trioxide is “reasonably anticipated to be a human carcinogen”, but that the available human data are “inadequate to evaluate the relationship between human cancer and exposure specifically to antimony trioxide or antimony in general”.

US National Toxicology Program (2018). Report on Carcinogens. Monograph on antimony trioxide. 19 October 2018.


The above items were taken from the December 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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