According to the recently released final report, there was clear evidence of carcinogenic activity (increased incidence of hepatoblastomas, uncommon malignant liver cancers) in male mice and some evidence of carcinogenic activity (hepatocellular carcinomas) in female mice administered kava kava extract by stomach tube at 250 mg/kg bw/day and above, 5 days/week, for 2 years. In rats, there was equivocal evidence of carcinogenic activity in males (based on slight increases in the incidences of common testicular tumours), but no evidence of carcinogenic activity in females administered up to 1000 mg/kg bw/day, 5 days/week, for 2 years.

The results of associated investigations undertaken by the NTP (2-week and 3-month studies and genotoxicity assays) are also presented in this report, together with a review of pertinent toxicity information.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of kava kava extract in F344/N rats and B6C3F1 mice (gavage studies). Dated March 2012. NTP TR 571. NIH Publication No. 12-5913.


The above item was taken from the April 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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