The NTP has finalised its technical report on the toxicology and carcinogenicity of vinylidene chloride, a common organic chemical used widely in polymer synthesis. The 2-year inhalation studies indicated “clear evidence of carcinogenic activity”, primarily based on increased incidences of malignant mesothelioma in the nasal passages of male rats, kidney tumours in male mice, and haemangiomas and haemangiosarcomas of all organs in female mice. There was “some evidence of carcinogenicity” in female rats, in which leukaemia and thyroid tumours were reported. A range of non-neoplastic lesions in the nose were reported in all treated groups. The findings of shorter-term (2-week and 3-month) studies, and genotoxicity assays are also reported.

US National Toxicology Program (2015). Technical report on the toxicology and carcinogenesis studies of vinylidene chloride (CAS No. 75‑35‑4) in F344/N rats and B6C3F1/N mice (inhalation studies). NTP TR 582. August 2015.

http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr582_508.pdf

 

The above items were taken from the October 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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