The NTP has released its finalised technical report on the toxicology of TBBPA, focused on carcinogenicity. Two-year gavage studies provide clear evidence of carcinogenic activity in female rats (an increased incidence of uterine tumours), equivocal evidence in male rats (a slightly increased incidence of testicular adenomas), and some evidence in male mice (an increased incidence of liver tumours). There was no evidence of carcinogenic activity in female mice.

US National Toxicology Program (2014). Technical report on the toxicology studies of tetrabromobisphenol A (CAS no. 79-94-7) in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). NTP TR 587. http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr587_508.pdf

 

The above items were taken from the October 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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