The NTP has finalised its technical report on the toxicology (including genotoxicity and carcinogenicity) of glycidamide. Glycidamide is a known genotoxin and has given positive results in in vitro and in vivo assays for gene mutation, DNA damage and chromosomal aberrations. The 2-year drinking water studies provided “clear evidence of carcinogenic activity” based on tumours at multiple sites in male and female rats and mice (as well as showing a range of non‑neoplastic effects). Since the same tumour sites were observed in rodents given acrylamide, it was concluded that the “carcinogenic activity of acrylamide is due to its metabolic conversion to glycidamide”.

US National Toxicology Program (2014). Technical report on the toxicology and carcinogenesis studies of glycidamide (CAS No. 5694-00-8) in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies). NTP TR 588.


The above items were taken from the April 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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