The NTP has released its finalised technical report on the toxicology (including genotoxicity and carcinogenicity) of β‑picoline. Two-year drinking water studies indicated “clear evidence of carcinogenic activity” in female mice (increased incidences of liver and lung tumours), “equivocal evidence” in male mice (equivocal findings related to incidences of lung tumours), “some evidence” in female rats (increased incidences of lung tumours) and “no evidence” in male rats. No evidence of genotoxicity was seen in Ames or in vivo micronucleus tests.
US National Toxicology Program (2014). Technical report on the toxicology and carcinogenesis studies of β-picoline in F344/N rats and B6C3F1/N mice (drinking water studies). NTP TR 580. http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr580_508.pdf
The above items were taken from the December 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)News Home Guest Write For Us? Contact Us