Draft NTP technical reports on the toxicology of four substances have recently been made available ahead of a May 2014 peer review panel meeting. The following are covered:

  • bromodichloroacetic acid
  • CIMSTAR 3800 (a metalworking fluid)
  • green tea extract
  • indole-3-carbinol

Bromodichloroacetic acid showed “clear evidence of carcinogenicity” in rats and mice. CIMSTAR 3800 gave “some evidence of carcinogenicity” in female mice and “equivocal evidence” in rats of both sexes. There was “clear evidence of carcinogenicity” for indole-3-carbinol in male mice and “some evidence of carcinogenicity” in female rats. The only evidence of carcinogenicity for green tea extract was equivocal in female mice.

US National Toxicology Program (2014). Draft NTP technical reports on the toxicology and carcinogenesis of:

Bromodichloroacetic acid. NTP TR 583. http://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2014/may/draft_tr583_508.pdf

CIMSTAR 3800. NTP TR 586. http://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2014/may/draft_tr586_508.pdf

Green tea extract. NTP TR 585. http://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2014/may/draft_tr585_508.pdf

Indole-3-carbinol. NTP TR 584. http://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2014/may/draft_tr584_508.pdf

The above items were taken from the May 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

News Home Guest Write For Us? Contact Us