A working group set up by AFSSET (the French Agency for Environmental and Occupational Health and Safety) was given the task of standardising a method for deriving TRVs (or VTRs, as they are known in France). These values (which are equivalent to the reference dose/concentration, minimal risk level or reference exposure level used in the US) are estimates of exposure, inhalation or oral, that are unlikely to cause any appreciable risk of deleterious effects in individuals (including vulnerable subgroups) over a period of time. In view of increasing concern about the possible effects on reproductive function of chemicals generally, the working group specifically addressed this area in a recent paper, concluding that a benchmark dose approach should be used wherever possible for estimating critical doses in these evaluations. The experts also offered advice on the application of appropriate uncertainty factors when establishing reprotoxic TRVs (Dor F. et al., Regulatory Toxicology and Pharmacology 2009, 55, 353; http://dx.doi.org/10.1016/j.yrtph.2009.08.006). {183677}

The above item was taken from the January 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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