In its 2010 monograph on the evaluation of carcinogenic risks to humans posed by alcohol and ethyl carbamate, IARC drew a causal relationship between alcoholic beverage consumption and colorectal cancer, with the regular daily consumption of around four alcoholic drinks (50 g alcohol) linked to an increased relative risk (RR) of 1.4. This association was not, however, quantified for lighter drinkers. To resolve this issue, a meta-analysis of a number of cohort and case-control studies has been performed. For moderate drinkers (of two to three alcoholic drinks per day), an RR of 1.21 was calculated, with an RR of 1.52 observed for heavy drinkers (of at least four alcoholic drinks per day). Increased RR was not seen as a result of light alcohol consumption (no more than one alcoholic drink per day), although a dose-risk analysis identified a significantly increased RR (of 1.07) related to the daily consumption of 10 g alcohol [approximately one alcoholic drink per day]. It was therefore determined that evidence of a link between the consumption of more than one alcoholic drink per day and the development of colorectal cancer is strong. Additionally, gender and geographical differences in relative risk of colorectal cancer due to alcohol consumption were explored.

Fedirko V. et al. (2011). Annals of Oncology 2011, 22, 1958; available at http://annonc.oxfordjournals.org/content/22/9/1958.full.pdf. {188607}

The above item was taken from the November 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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