Health Canada seeks comments (by 21 May) on its draft assessment of cadmium in drinking water. Renal toxicity was identified as the “best-characterised sensitive endpoint of concern” for oral exposure to cadmium, though effects on bone have also been reported. A tolerable daily intake (TDI) of 0.80 µg/kg bw was calculated based on a large meta‑analysis of epidemiological studies that measured the dose-response relationship between urinary biomarkers. From the TDI, a health-based value (HBV) in drinking water of 0.007 mg/L was proposed.

Health Canada (2019). Cadmium in drinking water. Guideline Technical Document for Public Consultation. March 2019. https://www.canada.ca/content/dam/hc-sc/images/programs/consultation-cadmium-drinking-water/Cadmium_in_Drinking_Water_01-29-2019_ENG.pdf

 

The above items were taken from the May 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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