Health Canada seeks comments (by 21 May) on its draft assessment of cadmium in drinking water. Renal toxicity was identified as the “best-characterised sensitive endpoint of concern” for oral exposure to cadmium, though effects on bone have also been reported. A tolerable daily intake (TDI) of 0.80 µg/kg bw was calculated based on a large meta‑analysis of epidemiological studies that measured the dose-response relationship between urinary biomarkers. From the TDI, a health-based value (HBV) in drinking water of 0.007 mg/L was proposed.

Health Canada (2019). Cadmium in drinking water. Guideline Technical Document for Public Consultation. March 2019.


The above items were taken from the May 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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