Health Canada seeks comments (by 9 November) on its draft assessment of 1,4-dioxane in drinking water. Liver toxicity (including cancer) was identified as the primary health concern associated with the ingestion of 1,4-dioxane, and a tolerable daily intake (TDI) of 5.4 µg/kg bw was calculated following benchmark dose (BMD) analysis of data from chronically exposed rats. From the TDI, a maximum acceptable concentration (MAC) in drinking water of 50 µg/L was proposed. These figures are expected to protect against cancer and non-cancer health effects.

Health Canada (2018). 1,4-Dioxane in drinking water. Guideline Technical Document for Public Consultation. August 2018. https://www.canada.ca/content/dam/hc-sc/documents/programs/consultation-1-4-dioxane-drinking-water/pub-eng.pdf

 

The above items were taken from the October 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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