Health Canada seeks comments (by 9 November) on its draft assessment of 1,4-dioxane in drinking water. Liver toxicity (including cancer) was identified as the primary health concern associated with the ingestion of 1,4-dioxane, and a tolerable daily intake (TDI) of 5.4 µg/kg bw was calculated following benchmark dose (BMD) analysis of data from chronically exposed rats. From the TDI, a maximum acceptable concentration (MAC) in drinking water of 50 µg/L was proposed. These figures are expected to protect against cancer and non-cancer health effects.

Health Canada (2018). 1,4-Dioxane in drinking water. Guideline Technical Document for Public Consultation. August 2018.


The above items were taken from the October 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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