A recently issued draft screening assessment report on bisphenol A, an industrial chemical used in the manufacture of polycarbonate plastic and epoxy resins, concludes that it may be entering the (Canadian) environment “in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health.” Dietary intake is the primary source of exposure to bisphenol A, and of particular concern is the exposure of newborn babies and infants up to 18 months of age (as a result of the compound’s release from polycarbonate baby bottles). In view of the available toxicokinetic data suggesting potential greater sensitivity of the pregnant woman/foetus and infant, and the findings in rodent studies of possible heightened susceptibility during stages of development, the gap between the maximum estimated exposure of infants (1.75‑4.3 μg/kg bw/day) and the effect levels identified in some laboratory animal studies (10 μg/kg bw/day) is not considered sufficient. The Canadian Government has therefore proposed a number of precautionary actions, including a ban on polycarbonate baby bottles, the development of stringent migration targets for bisphenol A from infant formula containers, and collaboration with industry to develop alternative food packaging and to develop a code of practice. There is now a 60-day public comment period, which ends on 18 June 2008.

[Health Canada. Draft screening assessment for phenol, 4,4′-(methylethylidine)bis- (Bisphenol A). April 2008. Available at with additional background information (including the proposed actions) accessible via on the internet.] {176228}

The above item is taken from the June 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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