IARCs latest addition to its prestigious series of monographs on the evaluation of carcinogenic risks to humans reports on the March 2009 IARC Working Group meeting to reassess the carcinogenicity of metals (beryllium, cadmium, chromium, nickel), arsenic, dusts, and fibres that have been previously classified as “carcinogenic to humans” (Group 1).

Beryllium and its compounds, cadmium and its compounds, chromium (VI) compounds and nickel compounds were reaffirmed as being “carcinogenic to humans” (Group 1), along with all forms of asbestos (and talc containing asbestiform fibres), erionite, leather dust, wood dust, and crystalline silica in the form of quartz or cristobalite.

While arsenic and inorganic arsenic compounds also remained within Group 1, dimethylarsinic acid and monomethylarsonic acid were classified as “possibly carcinogenic to humans” (Group 2B), and arsenobetaine and other organic arsenic compounds not metabolised in humans were “not classifiable as to their carcinogenicity to humans” (Group 3).

International Agency for Research on Cancer (2011). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 100. A review of human carcinogens. Part C: Arsenic, metals, fibres and dusts.


The above item was taken from the January/February 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).