Volume 101 of IARC’s prestigious series of monographs on the evaluation of carcinogenic risks to humans covers some chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination by-products.

All but one of the eighteen evaluated chemicals were placed in Group 2B (“possibly carcinogenic to humans”) due to “sufficient evidence of carcinogenicity in experimental animals”.

The exception – 2-nitrotoluene – was moved from Group 3 (“not classifiable as to its carcinogenicity to humans”) to Group 2A (“probably carcinogenic to humans”). This was on the basis of high incidences of early-onset tumours observed in rodents treated with 2-nitrotoluene, and the metabolic production of “an electrophilic, DNA-reactive compound that forms adducts in the liver”. It was considered that a similar pathway is likely to exist in humans.

Chapters on the following ten chemicals are currently available (those on the remaining eight chemicals will follow soon):

  • 1-amino-2,4-dibromoanthraquinone
  • anthraquinone
  • benzophenone
  • coconut oil diethanolamine condensate
  • cumene
  • 1,3-dichloro-2-propanol
  • diethanolamine
  • methyl isobutyl ketone
  • 3-monochloro-1,2-propanediol
  • 2-nitrotoluene

International Agency for Research on Cancer (2012). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 101. A review of human carcinogens. Some chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination by-products.

http://monographs.iarc.fr/ENG/Monographs/vol101/index.php

The above item was taken from the June 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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