In late 2009, Europe’s In Vitro Testing Industrial Platform (IVTIP) organised a meeting to discuss the US National Research Council’s 2007 vision and strategy for toxicity testing in the 21st century. Perhaps not surprisingly, IVTIP’s participants were in favour of NRC’s proposed approach, which steers away from traditional animal toxicity testing and focuses more on the identification of chemical-specific perturbations in key toxicity pathways (using new methods such as computational biology). However, in order for the transition to be made from current toxicity testing methodology, there are a range of issues that need to be addressed. These include the lack of human-specific test methods with adequate physiological relevance, the need for standardisation of test methods and the challenges of validating them, the poor understanding of the processes underlying healthy and diseased conditions in humans and of the difference between adverse and adaptive responses, and the current lack of acceptance of ‘alternative’ methods by regulatory authorities. Various key conditions were identified that need to be met in order to move forward on these issues (Berg N. et al., Toxicology in Vitro 2011, 25, 874; {187884}

The above item was taken from the September 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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