Full toxicological monographs from JECFA’s 78th meeting, held back in November 2013, detail the available data on the following veterinary drug residues, together with the Committee’s associated conclusions:

  • gentian violet: an acceptable daily intake (ADI) was deemed inappropriate due to this compound’s genotoxicity and carcinogenicity
  • lasalocid sodium: an ADI of 5 μg/kg bw was established, the critical effects being reproductive toxicity in rats and developmental toxicity in rabbits
  • recombinant bovine somatotropins: the previous decision of an ADI “not specified” for somagrebove, sometribove, somavubove and somidobove was reaffirmed
  • zilpaterol hydrochloride: an ADI of 0.04 μg/kg bw was set, based on tremors in exposed humans

In addition, JECFA maintained previously established ADIs of 0.3 and 0.5 μg/kg bw for derquantel and emamectin benzoate (full toxicological monographs were not prepared).

Joint FAO/WHO Expert Committee on Food Additives (2014). Toxicological evaluation of certain veterinary drug residues in food. Seventy-eighth meeting, Geneva, 5-14 November 2013. WHO Food Additives Series 69. World Health Organization. http://apps.who.int/iris/bitstream/10665/128550/1/9789241660693_eng.pdf?ua=1


The above items were taken from the October 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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