The technical report from JECFA’s 78th meeting in Geneva (held in November 2013) has been released. The main conclusions reached are as follows:

  • derquantel: the current acceptable daily intake (ADI) of 0.3 μg/kg bw was maintained
  • emamectin benzoate: an ADI of 0.5 μg/kg bw, set by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) in 2011, was confirmed
  • gentian violet: an ADI was considered inappropriate due to this compound’s genotoxicity and carcinogenicity
  • lasalocid sodium: an ADI of 5 μg/kg bw was derived, based on rodent reproductive and developmental toxicity data
  • recombinant bovine somatotropins: the previous decision was upheld of ADIs “not specified” for somagrebove, sometribove, somavubove and somidobove
  • zilpaterol hydrochloride: an ADI of 0.04 μg/kg bw was recommended, based on studies in asthmatics

Also discussed at this meeting were a risk-based decision-tree approach for the safety evaluation of residues of veterinary drugs, dietary exposure assessments, maximum residue limit (MRL) extrapolations between food animal species, the establishment of MRLs for residues in honey and, very briefly, the scope of MRLs relating to fish and seafood.

Joint FAO/WHO Expert Committee on Food Additives (2014). Evaluation of certain veterinary drug residues in food. Seventy-eighth meeting, Geneva, 5-14 November 2013. World Health Organization.

WHO Technical Report Series 988.

[Also: WHO Food Additives Series 69.]

The above items were taken from the September 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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