The first supplementary safety evaluation from JECFA’s eightieth meeting focuses on NDL-PCBs. Studies on the use of human breastmilk to estimate NDL-PCB body burdens were used to derive margins of exposure (MOEs) based on minimal effect doses. The margins were “considered to be adequate … to give some assurance that dietary exposures to NDL-PCBs are unlikely to be of health concern for adults and children”, although data were insufficient to allow the risks of combined exposures to individual NDL-PCBs to be assessed. JECFA did, however, note that “the MOEs were particularly conservative”, being based on minimal effects on the liver and thyroid, which were not of clear toxicological significance.

Joint FAO/WHO Expert Committee on Food Additives (2016). Safety evaluation of certain food additives and contaminants. Supplement 1: Non-dioxin-like polychlorinated biphenyls. WHO Food Additives Series 71-S1. http://apps.who.int/iris/bitstream/10665/246225/1/9789241661713-eng.pdf

 

The above items were taken from the December 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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