The technical report from JECFA’s June 2014 meeting in Geneva has been released. The main conclusions are:

  • Carrageenan in infant formulae: use at concentrations of up to 1000 mg/L is not of concern.
  • Citric and fatty acid esters of glycerol (“CITREM”) in infant formulae: no toxicological concerns at concentrations up to 9 g/L.
  • Lutein esters from Mexican marigold (Tagetes erecta): a temporary acceptable daily intake (t-ADI) of “not specified” was established.
  • Octenyl succinic acid (OSA)-modified gum arabic: the t-ADI “not specified” will be withdrawn unless adequate data to complete the safety evaluation are submitted by the end of 2015.
  • Paprika extract used as a food colour: an ADI of 1.5 mg/kg bw (as total carotenoids) was established.
  • Pectin in infant formulae: concern was expressed that growth might be impaired at the maximum proposed use level of 0.5%.

A number of flavouring agents in the following groups were also evaluated. The majority were considered to be of “no safety concern” based on current estimates of dietary exposure:

  • aliphatic and alicyclic hydrocarbons
  • aliphatic and aromatic ethers
  • ionones and structurally-related substances (additional data are required to complete the evaluation of trans-α-damascone)
  • miscellaneous nitrogen-containing substances
  • monocyclic and bicyclic secondary alcohols, ketones and related esters
  • phenol and phenol derivatives
  • phenyl-substituted aliphatic alcohols and related aldehydes and esters (one, (±)-2-phenyl-4-methyl-2-hexenal, was not evaluated due to concerns over genotoxicity; JECFA also noted that evaluations of other α,β‑unsaturated aldehydes in this group should be reconsidered at a future meeting)
  • sulphur-containing heterocyclic compounds (2,5-dimethyl-3-acetylthiophene was considered unsuitable for use as a flavouring agent due to observed in vivo genotoxic potential)

Joint FAO/WHO Expert Committee on Food Additives. Seventy-ninth meeting. Geneva, 17-26 June 2014. Technical Report Series 990. http://apps.who.int/iris/bitstream/10665/150883/1/9789241209908_eng.pdf

 

The above items were taken from the March 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

 

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