The technical report from JECFA’s June 2014 meeting in Geneva has been released. The main conclusions are:

  • Carrageenan in infant formulae: use at concentrations of up to 1000 mg/L is not of concern.
  • Citric and fatty acid esters of glycerol (“CITREM”) in infant formulae: no toxicological concerns at concentrations up to 9 g/L.
  • Lutein esters from Mexican marigold (Tagetes erecta): a temporary acceptable daily intake (t-ADI) of “not specified” was established.
  • Octenyl succinic acid (OSA)-modified gum arabic: the t-ADI “not specified” will be withdrawn unless adequate data to complete the safety evaluation are submitted by the end of 2015.
  • Paprika extract used as a food colour: an ADI of 1.5 mg/kg bw (as total carotenoids) was established.
  • Pectin in infant formulae: concern was expressed that growth might be impaired at the maximum proposed use level of 0.5%.

A number of flavouring agents in the following groups were also evaluated. The majority were considered to be of “no safety concern” based on current estimates of dietary exposure:

  • aliphatic and alicyclic hydrocarbons
  • aliphatic and aromatic ethers
  • ionones and structurally-related substances (additional data are required to complete the evaluation of trans-α-damascone)
  • miscellaneous nitrogen-containing substances
  • monocyclic and bicyclic secondary alcohols, ketones and related esters
  • phenol and phenol derivatives
  • phenyl-substituted aliphatic alcohols and related aldehydes and esters (one, (±)-2-phenyl-4-methyl-2-hexenal, was not evaluated due to concerns over genotoxicity; JECFA also noted that evaluations of other α,β‑unsaturated aldehydes in this group should be reconsidered at a future meeting)
  • sulphur-containing heterocyclic compounds (2,5-dimethyl-3-acetylthiophene was considered unsuitable for use as a flavouring agent due to observed in vivo genotoxic potential)

Joint FAO/WHO Expert Committee on Food Additives. Seventy-ninth meeting. Geneva, 17-26 June 2014. Technical Report Series 990.


The above items were taken from the March 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)


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