ACGIH Association Advancing Occupational and Environmental Health
ACNFP Advisory Committee on Novel Foods and Processes
ADE Acceptable daily exposure
ADI Acceptable daily intake
ADI “not specified” JECFA term for a substance considered to have a very low toxicity for which no safe upper-limit of intake is established
AHAW EFSA Panel on Animal Health and Welfare
AI Acceptable intake
AI Adequate intake
AF Assessment factor
ANS EFSA Panel on Food Additives and Nutrient Sources Added to Food
AOEL Acceptable operator exposure level
AOP Adverse outcome pathway
APVMA Australian Pesticides and Veterinary Medicines Authority
ARfD Acute (oral) reference dose
AS Allometric scaling
ATSDR Agency for Toxic Substances and Disease Registry
BfR The Federal Institute for Risk Assessment
BIBRA British Industrial Biological Research Association
BMC Benchmark concentration
BMCL Lower 95% confidence limit on the benchmark concentration
BMCL10 Lower 95% confidence limit on the benchmark concentration corresponding to a 10% relative change in the end-point
BMD10 Benchmark dose for a 10% response
BMDL10 Lower 95% confidence limit on the benchmark dose for a 10% response
BPR Biocidal Products Regulation (EU) No 528/2012
BW Body weight
CAS RN Chemical Abstracts Service Registry Number
CEF EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
CICAD WHO Concise International Chemical Assessment Documents
CIR Cosmetic Ingredient Review
C&L Classification and labelling
Chesar Chemical safety assessment and reporting tool
CLP Classification, labelling and packaging (Regulation (EC) No 1272/2008)
CMR Carcinogenic, mutagenic and reprotoxic substance
COC Committee on Carcinogenicity of Chemicals In Food, Consumer Products and the Environment (UK)
COM Committee on Mutagenicity of Chemicals In Food, Consumer Products and the Environment (UK)
CONTAM EFSA Panel on Contaminants in the Food Chain
Cosmetics Regulation (EC) 1223/2009
COT Committee on Toxicity of Chemicals In Food, Consumer Products and the Environment (UK)
DECOS Dutch Expert Committee on Occupational Safety
DMEL Derived minimal effect level
DNEL Derived no effect level
DRV Dietary reference value
DSD Dangerous Substances Directive (67/548/EEC)
DPD Dangerous Preparations Directive (1999/45/EC)
EC European Commission
EC3 Derived from the LLNA, the EC3 is the estimated concentration of a test substance needed to produce an SI of 3. ECETOC definitions of potency are: extreme sensitizer (EC3 value <0.1); strong sensitizer (EC3 >0.1 – ≤1); moderate sensitizer (EC3 value >1 – <10; and weak sensitizer (EC3 value >10).
EC50 Half maximal effective concentration
ECETOC European Centre for Ecotoxicology and Toxicology of Chemicals
ED50 Half maximal effective dose
ECDD WHO expert committee on drug dependence
ECHA European Chemicals Agency
EFSA European Food Safety Authority
EHC Environmental Health Criteria
EMA European Medicines Agency
EPA Environmental Protection Agency
ESL Effects screening level
EU European Union
FEEDAP EFSA Panel on Additives and Products or Substances used in Animal Feed
FSANZ Food Standards Australia New Zealand
FAO Food and Agriculture Organization of the United Nations
FDA Food and Drugs Administration
GESTIS IFA database on hazardous substances
GHS Globally Harmonized System of Classification and Labelling of Chemicals
GLP Good laboratory practice
GRAS Generally recognised as safe
HBGV Health-based guidance value
HC Health Canada
HCV Health Criteria Value
HERA Human and Environmental Risk Assessment on ingredients of household cleaning products
IARC International Agency for Research on Cancer
IC50 Median inhibitory concentration
ICD International Statistical Classification of Diseases and Related Health Problems
ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
i.p. Intraperitoneal
i.v. Intravenous
IATA Integrated approach on testing and assessment
IFA Institute for Occupational Safety and Health
IPCS International Programme on Chemical Safety
IRIS Integrated Risk Information System (US EPA)
ISO International Organization for Standardization
ITAP Initial Targeted Assessment Profile
ITAR Initial Target Assessment Report
IUCLID International Uniform Chemical Information Database
JECFA Joint FAO/WHO Expert Committee on Food Additives
JMPR Joint FAO/WHO meeting on Pesticide Residues
KE Key event
LC0 Maximum tolerable concentration
LC50 Median lethal concentration (i.e. the concentration that is lethal to 50% of the exposed group)
LD0 Maximum tolerable dose
LD50 Median lethal dose (i.e. the dose that is lethal to 50% of the exposed group)
LLNA Local lymph node assay
LOAEC Lowest observed adverse effect concentration
LOEC Lowest observed effect concentration
LOAEL Lowest observed adverse effect level
LOEL Lowest observed effect level
MAC Maximum acceptable concentration (in drinking water)
MAL Maximum acceptable level
MET10 10% minimum elicitation threshold
mg/kg bw Milligrams per kilogram of body weight
MIE Molecular initiating event
MoA Mode of action
MoE Margin of exposure (risk assessment)
MoS Margin of safety
MRL Minimal risk level
MRL Maximum residue level
MTD Maximum tolerated dose
NDA EFSA Panel on Dietetic Products, Nutrition and Allergies
NESIL No expected sensitisation induction level
NICNAS National Industrial Chemicals Notification and Assessment
NIOSH National Institute for Occupational Safety and Health
NOAEC No observed adverse effect concentration
NOAEL No observed adverse effect level
NOEC No observed effect concentration
NOEL No observed effect level
NOGEL No observed genotoxic effect level
NRC National Research Council
NTP National Toxicology Program
OECD Organization for Economic Co-operation and Development
OEL Occupational exposure limit
OEHHA Office of Environmental Health Hazard Assessment
PBPK Physiologically based pharmacokinetic modelling
PDE Permitted Daily Exposure
PEC Predicted environmental concentration
PHE Public Health England
PNEC Predicted no-effect concentration
POD Point of Departure
p.o. Peroral
PPR EFSA Panel on Plant Protection Products and their Residues
PRI Population reference intake
Proposition 65 California’s Safe Drinking Water and Toxic Enforcement Act
QSAR Quantitative structure–activity relationship
RAC Committee for Risk Assessment
RCR Risk Characterisation Ratio
RD50 The concentration required to reduce the respiratory rate by 50%
RDA Recommended dietary allowance
RDI Recommended daily intake
REACH Registration, Evaluation, Authorisation & Restriction of Chemicals; Regulation (EC) No 1907/2006
ReV Reference Value
RfC Reference concentration (for chronic inhalation exposure)
RfD Reference dose (for chronic oral exposure)
RIFM Research Institute for Fragrance Materials
ROC NTP Report on Carcinogens
RPA Reference point for action
S9 Induced mammalian liver post-mitochondrial fraction used for metabolic activation
SAR Structure–activity relationship
SACN Scientific Advisory Committee on Nutrition
s.c. Subcutaneous
SCCS Scientific Committee on Consumer Safety
SCHER Scientific Committee on Health and Environmental Risks
SCHEER Scientific Committee on Health, Environmental and Emerging Risks
SCENIHR Scientific Committee on Emerging and Newly Identified Health Risks
SCOEL Scientific Committee on Occupational Exposure Limits
SI Stimulation Index. Derived from the LLNA, the SI is the ratio of lymphocyte proliferation in a treated group to that in the vehicle control group. An SI of ≥3 is considered a positive result for sensitisation
SIAM SIDS intial assessment meeting
SIAP SIDS Initial Assessment Profile
SIAR SIDS Initial Assessment Report
SIDS Screening Information Dataset
STEL Short term exposure limit
T25 The chronic daily dose in mg/kg bw which will give 25% of the animals tumours at a specific tissue site
TC Tolerable concentration
TCA Tolerable concentration in air
TD50 The chronic daily dose in mg/kg bw which will give 50% of the animals tumours at a specific tissue site
TCEQ The Texas Committee on Environmental Quality
TG Test guideline
TGA Therapeutics Goods Administration
TDI Tolerable daily intake
TLV Threshold limit value
TPD Tobacco Products Directive (2014/40/EU)
TPD2 Revision of the Tobacco Products Directive
TSCA Toxic Substances Control Act
TTC Threshold of Toxicological Concern
TWA Time weighted average
TWI Tolerable weekly intake
UF Uncertainty factor
USEPA United States Environmental Protection Agency
VKM Norwegian Scientific Committee for Food Safety
WHO World Health Organization
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