Literature searching

Our scientists know that a quality risk assessment relies upon quality data. While reliable data may be obtained by commissioning laboratory testing, the time and costs involved (together with the additional ethical issues around testing on vertebrates) encourage our clients to ensure that any relevant existing data are captured first. A good-quality study in the publically-available scientific literature may negate the need for further laboratory testing, potentially saving thousands of pounds.

When it comes to searching for available (eco)toxicity data, we are ideally placed to help. For decades, we have performed daily searches of a tried-and-tested series of external databases (including some subscription-only packages). We also have exclusive use of our in-house database, TRACE, giving us invaluable access to Expert Group and primary reports which are not always well-covered elsewhere. All of the documents on TRACE have been individually selected and indexed by our expert toxicologists.

Our toxicological expertise and extensive knowledge of the wide-ranging data sources mean that we can easily tailor our searches to you. Years of experience make us well-placed to judge which hits and search terms are likely to be relevant to your areas of interest (e.g. genotoxicity, acute toxicity, inhalation), potentially saving you a great deal of time trawling through irrelevant hits. TRACE, in particular, can be focused directly to your needs with just a few clicks, providing a much more relevant output than comparable external databases.

It is also worth noting that data-poor target compounds may have data-rich structural analogues or metabolites/precursors. Quality data on these read-across compounds may also be sufficient to avoid laboratory testing. We can run parallel literature searches on target and read-across compounds, and can provide you with the resulting bibliographic details in a comprehensive data-matrix.

Needless to say, our expertise in literature searching is invaluable in our day-to-day toxicological work. We have tailored strategies in place for a range of sectors including:

Recent work in this field

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