When administered by the intratracheal route, MWCNTs have been shown to persist in the lungs of rats (see the October 2005 issue of Toxicology and Regulatory News). Using intratracheal doses of 2.3 or 9.1 mg/kg bw, Belgian investigators have now rather worryingly demonstrated that MWCNTs (of average outer diameter 11.3 nm and length 0.7 μm) can induce chromosome damage (micronuclei) in the lung cells of rats. This genotoxic potential was confirmed by in vitro studies using rat and human cells, which further suggested that MWCNTs had the capacity to induce both aneugenic and clastogenic events (i.e. changes in the normal chromosome number as well as direct chromosome damage) (Muller J. et al., Carcinogenesis 2008, 29, 427). {175756}

The above item is taken from the May 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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