The NTP has issued its final technical report on the toxicology (including genotoxicity) and carcinogenicity of 2,3‑butanedione.

There was “some evidence of carcinogenicity” of 2,3-butanedione to male and female Wistar rats exposed (whole‑body) for 6 hours/day, 5 days/week, for 105 weeks. Both sexes displayed an increased incidence of an uncommon carcinoma of the nose, with males also showing an increased incidence of papilloma in this tissue. There was “equivocal evidence of carcinogenicity” in female mice, based on an increased incidence of nasal adenocarcinoma, but “no evidence of carcinogenicity” in male mice exposed to concentrations of up to 50 ppm for 2 years. Non‑neoplastic lesions were reported in the nose, larynx, trachea, lungs and eyes of male and female mice and rats.

US National Toxicology Program (2018). NTP Technical Report on the toxicology and carcinogenesis studies of 2,3-butanedione in Wistar Han rats and B6C3F1/N mice (inhalation studies). NTP TR 593. Final. August 2018. https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr593_508.pdf

 

The above items were taken from the November 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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