The NTP has released the final version of its technical report on the toxicology (including genotoxicity) and carcinogenicity of DE-71 (a pentabromodiphenyl ether mixture). The 2-year gavage studies indicated “clear evidence of carcinogenic activity” based on liver tumours in rats and mice of both sexes. Increased incidence of neoplastic lesions in the thyroid and pituitary glands in male rats were also considered treatment related. The report also covers a range of non‑neoplastic effects.

US National Toxicology Program (2016). Technical report on the toxicology studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] (CAS No. 32534-81-9) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in Wistar Han rats and B6C3F1/N mice (gavage studies). NTP TR 589. February 2016.

http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr589_508.pdf

 

The above items were taken from the March 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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