The NTP has finalised the technical report on the toxicology (including genotoxicity) and carcinogenicity of PFOA. Several genotoxicity studies have been carried out on PFOA producing conflicting results. A 2-year dietary study using Sprague Dawley rats revealed “clear evidence of carcinogenic activity” in males, identifying higher incidences of liver (hepatocellular) and pancreatic (acinar cell) tumours. There was also “some evidence of carcinogenic activity” in the pancreas of females (acinar cell adenomas / adenocarcinomas). In addition, there were higher incidences of non-neoplastic lesions in the liver and pancreas of male rats and in the liver, kidney, forestomach and thyroid gland of female rats.

US National Toxicology Program (2020). NTP Technical Report on the toxicology and carcinogenesis study of perfluorooctanoic acid (CAS No. 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) rats. NTP TR 598. May. https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr598_508.pdf

 

The above items were taken from the June 2020 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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