The NTP has published its final technical reports on the toxicology (including genotoxicity) and carcinogenicity of bromodichloroacetic acid (which can be formed in drinking water as a side-reaction in some disinfection processes)  and CIMSTAR 3800 (a metalworking fluid).

The 2-year oral (drinking water) studies of bromodichloroacetic acid indicated “clear evidence of carcinogenic activity” in rats and mice of both sexes. This was based on an increased incidence of malignant mesothelioma and skin tumours in male rats, and tumours of the mammary glands of female rats, the liver of male and female mice, and also of the Harderian gland of male mice.

In lifetime inhalation studies, CIMSTAR 3800 gave “some evidence of carcinogenicity” in female mice, based on lung and thyroid tumours, but “no evidence of carcinogenicity” in male mice. “Equivocal evidence” was reported in rats, with an increased incidence of tumours reported in the prostate of males, and the skin and uterus of females.

US National Toxicology Program (2015). Technical report on the toxicology studies of bromodichloroacetic acid (CAS No. 71133-14-7) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). NTP TR 583. October 2015.http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr583_508.pdf

Technical report on the toxicology studies of CIMSTAR 3800 in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of CIMSTAR 3800 in Wistar Han [Crl:WI (Han)] rats and B6C3F1/n mice (inhalation studies). NTP TR 586. September 2015. http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr586_508.pdf

 

The above item was taken from the November 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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