The NTP (NIEHS) has issued a draft monograph on the long-term neurological effects following acute exposure to the highly toxic organophosphorus nerve agent, sarin. Sarin was found to suppress cholinesterase production in the initial time period after exposure (>24 hours – 7 days). In the intermediate time period following exposure (8 days – 1 year), suppression of cholinesterase was maintained and ocular effects, effects on learning and memory and nervous system tissues were deemed to be associated with sarin. After more than 1 year following exposure (extended time period) effects on learning and memory and morphological and histopathological changes in nervous system tissues were found to be related to sarin neurotoxicity. The NTP concluded that “acute sarin exposure is suspected to be a neurological hazard to humans” at all three timepoints.

US National Toxicology Program (2018). Report on Carcinogens. Draft NTP Monograph on Systematic Review of Long-Term Neurological Effects Following Acute Exposure to the Organophosphorus Nerve Agent Sarin. 18 November 2018.


The above items were taken from the January/February 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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