The OECD has issued a draft guideline describing Defined Approaches (DAs) for the evaluation of skin sensitisation potential, together with a comprehensive supporting document. Three DAs are discussed and reviewed, the AOP-based “2 out of 3” approach and two associated integrated testing strategies, with a focus on the use of in chemico/in vitro testing methods to predict hazard and potency.

Organisation for Economic Cooperation and Development (2019). Draft OECD guideline on defined approaches for skin sensitisation. September.

Supporting document for evaluation and review of draft guideline (GL) for defined approaches (DAs) for skin sensitisation.


The above items were taken from the December 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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