OECD invites comments (by 13 September) on a draft updated test guideline (TG 458) and a draft test guideline (not yet numbered). Both relate to in vitro methods for detecting potential endocrine disrupting chemicals, which utilise the androgen receptor (AR), a nuclear receptor that can mediate an endocrine disruption response by acting as a transcription factor. The new TG method uses the 22Rv1/MMTV_GR-KO cell line (with minimal glucocorticoid receptor-mediated response) to detect and quantitatively measure androgen and anti-androgen activities, using luciferase as a reporter gene.

Organisation for Economic Cooperation and Development (2019). Draft guidelines for the testing of chemicals. Accessible via: http://www.oecd.org/env/ehs/testing/section4-health-effects.htm


The above items were taken from the September 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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