Work on the development and use of the OECD (Q)SAR Application Tool Box continues. Two recently issued OECD reports (Parts 1 and 2, both dated 4 June 2010) describe an expert consultation meeting that was held on 20 October 2009 to evaluate a revised set of structural alerts for estimating covalent binding of chemicals with DNA. Annex 3 of the Part 1 report gives detailed structural information on a new profiling approach that was created following the mapping of existing structural alerts for genotoxicity. A total of 56 new or re-defined alerts have been created (crossing six broad organic chemistry mechanisms); these evidently represent the most comprehensive listing of structural alerts for DNA binding currently available.

[Organisation for Economic Co-operation and Development (2010). Report of the expert consultation on scientific and regulatory evaluation of organic chemistry mechanism-based structural alerts for the identification of DNA binding chemicals. OECD Series on Testing and Assessment Number 120. ENV/JM/MONO(2010)8/Part1 and ENV/JM/MONO(2010)8/Part2. These documents are available at http://www.oecd.org/dataoecd/10/59/45401393.pdf and http://www.oecd.org/dataoecd/10/58/45401403.pdf respectively on the internet.] {185541}

The above item was taken from the August 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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