The OECD has released three case studies using an integrated approach to test and assess chemicals:

  • Grouping and read-across used to deduce the subchronic repeated-dose toxicity of simple aryl alcohol alkyl carboxylic esters.
  • Grouping and read-across for nanomaterials based on the genotoxicity of titanium dioxide nanoparticles.
  • Prioritisation and hazard characterisation used to test and assess the estrogenicity of substituted phenols.

Organisation for Economic Cooperation and Development (2018). Case study on:

the use of integrated approaches for testing and assessment for sub-chronic repeated-dose toxicity of simple aryl alcohol alkyl carboxylic esters: read-across. ENV/JM/MONO(2018)29. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2018)29&docLanguage=En

grouping and read-across for nanomaterials ─ genotoxicity of nano-TiO2. ENV/JM/MONO(2018)28.

http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2018)28&docLanguage=En

the use of integrated approaches for testing and assessment (IATA) for estrogenicity of the substituted phenols. ENV/JM/MONO(2018)26. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2018)26&docLanguage=En

 

The above items were taken from the December 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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