A retrospective analysis of reproductive toxicity data from nearly 500 two-generation studies was performed, in the context of evaluating the proposed Extended One Generation Reproductive Toxicity Study (EORGTS). The aim was to determine whether the production of a 2nd generation would alter the final conclusions on hazard characterisation for risk assessment or for GHS chemical hazard classification; the majority of experts involved agreed that this would rarely occur. However, a few disagreed on the basis of some provided examples and remaining scientific uncertainties with the analysis.

Organisation for economic Co-operation and Development. Report on the Retrospective Analysis of 2-Generation Reprotoxicity Data. Series on Testing and Assessment No.176. July 2012.

http://search.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono(2012)21&doclanguage=en

 

The above item was taken from the November 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).