A retrospective analysis of reproductive toxicity data from nearly 500 two-generation studies was performed, in the context of evaluating the proposed Extended One Generation Reproductive Toxicity Study (EORGTS). The aim was to determine whether the production of a 2nd generation would alter the final conclusions on hazard characterisation for risk assessment or for GHS chemical hazard classification; the majority of experts involved agreed that this would rarely occur. However, a few disagreed on the basis of some provided examples and remaining scientific uncertainties with the analysis.

Organisation for economic Co-operation and Development. Report on the Retrospective Analysis of 2-Generation Reprotoxicity Data. Series on Testing and Assessment No.176. July 2012.



The above item was taken from the November 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).