Amendments to the 15 test guidelines (TGs) listed below have recently been finalised and adopted by the OECD. Of particular note is the inclusion of endocrine-related endpoints in the updated TGs for 90-day repeated dose toxicity (TG 408) and prenatal developmental toxicity (TG 414).

  • TG 408: repeated dose 90-day oral toxicity study in rodents
  • TG 412: 28-day (subacute) inhalation toxicity study
  • TG 413: 90-day (subchronic) inhalation toxicity study
  • TG 414: prenatal developmental toxicity study
  • TG 433: acute inhalation toxicity: fixed concentration procedure
  • TG 438: isolated chicken eye test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage
  • TG 442B: local lymph node assay (BRDU-ELISA or –FCM)
  • TG 442D: in vitro skin sensitisation (ARE-Nrf2 Luciferase Test Method)
  • TG 442E: in vitro skin sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for skin sensitisation
  • TG 443: extended one-generation reproductive toxicity study
  • TG 451: carcinogenicity studies
  • TG 452: chronic toxicity studies
  • TG 453: combined chronic toxicity/carcinogenicity studies
  • TG 491: short time exposure in vitro test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage
  • TG 492: reconstructed human cornea-like epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or for serious eye damage.

Organisation for Economic Cooperation and Development (2018). Guidelines for the testing of chemicals. https://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788

 

The above items were taken from the August 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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