The following seven AOPs have been approved by the Extended Advisory Group of Molecular Screening and Toxicogenomics, and have now been made available for review and endorsement by the Working Group of the National Coordinators of the Test Guidelines Programme and the Working Party on Hazard Assessment:

  • 6: PPARα antagonism leading to body-weight loss
  • 10: Blocking iGABA receptor ion channel leading to seizures
  • 21: AhR mediated mortality
  • 42: TPO inhibition and altered neurodevelopment
  • 54: NIS inhibition and learning and memory impairment
  • 131: AHR activation-uroporphyria
  • 150: AHR activation to ELS mortality, via VEGF

Organisation of Economic Co-operation and Development (2019). Draft Guidance and Review Documents/Monographs. Available via:


The above items were taken from the April 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

News Home Guest Write For Us? Contact Us