Skin+ and epiCS and are two new in vitro assays (now incorporated in OECD TG 439) that use reconstructed human epidermis (RhE) to assess the skin irritation potential of chemicals. The OECD has issued a report of the peer review of the test methods, concluding that both are scientifically similar to the validated RhE test methods for irritation in terms of their “essential test method components” and “reproducibility and predictive capacity”.

Organisation for Economic Co-operation and Development (2019). Reports of the peer reviews of the epiCS and Skin+ test methods in view of their inclusion in test guideline 439 on in vitro skin irritation. Series on testing and assessment No. 299. ENV/JM/MONO(2019)15. 28 August 2019.


The above items were taken from the October 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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