The OECD has been developing guidance documents and tools for the use of alternative methods in chemical safety assessment, such as (Q)SAR, read-across (chemical categories) and Adverse Outcome Pathways (AOPs), for incorporation into IATA. Several case studies on uses of IATA have recently been published by the OECD; a separate report discusses the uncertainties of each. The case studies cover the following topics:

  • 90-day rat oral repeated-dose toxicity for selected n-alkanols
  • 90-day rat oral repeated-dose toxicity for selected 2-alkyl-1-alkanols
  • chemical safety assessment workflow based on exposure considerations and non-animal methods.
  • pesticide cumulative risk assessment & assessment of lifestage susceptibility
  • repeated-dose toxicity of phenolic benzotriazoles

Organisation for Economic Cooperation and Development (2017). Series on Testing & Assessment No. 270-275. Available via:


The above items were taken from the November 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

News Home Guest Write For Us? Contact Us