The OECD has been developing guidance documents and tools for the use of alternative methods in chemical safety assessment, such as (Q)SAR, read-across (chemical categories) and Adverse Outcome Pathways (AOPs), for incorporation into IATA. Several case studies on uses of IATA have recently been published by the OECD; a separate report discusses the uncertainties of each. The case studies cover the following topics:

  • 90-day rat oral repeated-dose toxicity for selected n-alkanols
  • 90-day rat oral repeated-dose toxicity for selected 2-alkyl-1-alkanols
  • chemical safety assessment workflow based on exposure considerations and non-animal methods.
  • pesticide cumulative risk assessment & assessment of lifestage susceptibility
  • repeated-dose toxicity of phenolic benzotriazoles

Organisation for Economic Cooperation and Development (2017). Series on Testing & Assessment No. 270-275. Available via: http://www.oecd.org/chemicalsafety/testing/series-testing-assessment-publications-number.htm

 

The above items were taken from the November 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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