Draft updates to the following guidelines have been released by OECD:

  • Test Guideline 474 (mammalian erythrocyte micronucleus test)
  • Test Guideline 475 (mammalian bone marrow chromosomal aberration test)
  • Test Guideline 478 (rodent dominant lethal test)
  • Test Guideline 483 (mammalian spermatogonial chromosomal aberration test)

OECD has also released proposals for updating:

  • Test Guideline 473 (in vitro mammalian chromosomal aberration test)
  • Test Guideline 487 (in vitro mammalian cell micronucleus test)

Also recently released is a draft report on statistical issues related to OECD in vitro genotoxicity test guidelines 473 and 487.

There is a request for public comments by 6 November 2013 for the draft updates and by 4 November 2013 for the proposals and related statistical report.

Organisation for Economic Co-operation and Development. September 2013.

All documents available via http://www.oecd.org/env/ehs/testing/section4healtheffects.htm


The above item was taken from the November 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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