Consideration of HCV data on two substances present in food

Background

The client was interested in decisions made by the Scientific Committee for Food (SCF) on two food constituents (one a single chemical, the other a group) in the 1990s, which have not since been updated. For the single chemical, no acceptable daily intake (ADI) or tolerable daily intake (TDI) had been established, while the chemical group was assigned a temporary TDI.

Client

A multinational food products company.

Project goals

Bibra was asked to consider whether more recent data on two substances support, or refute, SCF’s previous opinions on health criteria values (HCVs) including ADIs and TDIs.

Approach

In line with the client’s request, a staged approach was adopted, comprising:

1.   Literature searches for studies and reports published since the SCF decisions

2.   An assessment of the impact of these new studies, with the client informed of key findings

3.   A draft report discussing the critical data

4.   Derivation of a new oral HCV, if required, and documentation of this process

Project outcome

For the single chemical, a new 90-day study was identified, which allowed for a TDI to be calculated through the application of appropriate uncertainty factors to the rat no-observed-adverse-effect level (NOAEL). The existing data on the chemical group, meanwhile, did not suggest that the existing temporary TDI should be lowered, and did provide some support for an increase.

Bibra project team

Beth O’Connell
James Hopkins

 

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