Preparation of chemical toxicology reviews for the household products section of a global organisation


A global producer of a range of well-known household products.


Bibra scientists were asked to review the available toxicology data on specific compounds or groups of compounds that were present in the client’s products. These reviews were to provide key data covering health criteria values, occupational exposure levels, regulatory status, human health effects (including target organs and no-observed-adverse-effect levels), environmental effects (including PECs and PNECs), pharmacokinetics, and routes of exposure.

Project Goals

The aim was to provide an overview of the key mammalian toxicity and ecotoxicology data on each compound, making good use of existing Expert Group reports but also searching the primary literature for any subsequent developments that might have an impact on the compound’s status.


The bibra toxicologists have many years of experience in the preparation of hazard reports on chemicals. Our first port of call was our own in-house database (TRACE) and databank, which we have been running for over 50 years. This provides a quick and efficient route to Expert Group evaluations on the chemicals of interest, and is more up to date and comprehensive in its indexing than is eChemPortal, with a wider coverage of Expert Groups. All such documents in TRACE will have been chemically indexed, and any relevant reviews can be retrieved by a simple search on the CAS Registry number and an appropriate code (for expert reviews). The best of these were used as the basis for the toxicological reviews, as they identify the key data. In addition, we conducted searches of the primary literature published since the Expert Group reports, using TRACE, TOXNET and eChemPortal at the very least, to ensure that there had been no further developments that might have altered the compound’s toxicological status. Having summarised all of the key data, we went back over the primary papers identified via TRACE and the various external databases, to ensure that there were no gaps in the data that might have been missed by the Expert Groups.

Project Outcome

We successfully completed a series of toxicological reviews on individual compounds or groups of compounds, according to a strict timetable. These provided the client with up-to-date evaluations of the critical data on health criteria values, occupational exposure levels, mammalian toxicity and ecotoxicology, pharmacokinetics, routes of exposure and regulatory status.

Project Leaders

Tanya Diver

Consumer Product Safety Assessments

More recent work Info about us Meet our team