A report on the 2008 workshop of the European SCARLET (StruCture-Activity Relationships Leading ExperTs in mutagenicity and carcinogenicity) project has provided a comprehensive overview of the current position on predictive models for carcinogenicity and mutagenicity. In silico models based on computer programmes could prove very useful (for example in prioritisation, screening, mechanistic studies and providing support for risk assessment), and offer at least two promising specific applications, the classification of potential carcinogens and mutagens, and the prediction of potency. The workshop report raises a number of interesting issues and suggests how traditional and new data could be incorporated into successful predictive models to provide a new approach for assessing genotoxicity and carcinogenicity “by linking chemical structures to biological effects with the introduction of new molecular-level assays to yield potential mechanistic insights” (Benfenati E. et al., Journal of Environmental Science and Health Part C 2009, 27, 57; http://dx.doi.org/10.1080/10590500902885593). {181928}

The above item was taken from the July 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

News Home Guest Write For Us? Contact Us