ECHA’s Committee for Risk Assessment (RAC) has recently adopted scientific opinions on occupational exposure for 4,4’-methylene-bis-[2-chloroaniline] (MOCA), and for arsenic (As) acid and its inorganic compounds. The critical endpoint for these substances is non-threshold genotoxic carcinogenicity, hence no Occupational Exposure Limit (OEL) could be established. Unit cancer risk values for workers’ exposure by the inhalation route were reported to be 9.65 x 10-6 per µg/m3 (MOCA) and 1.4 x 10-4 per μg As/m3, meaning that lifetime daily exposures to 1.04 μg MOCA/m3 or 0.07 μg As/m3 are equivalent to an excess cancer risk of 1 in 100,000. Analogous values by the dermal route were 3.38 x 10-5 per µg MOCA/kg bw/day and 6.4 x 10-6 per μg As/kg bw/day, equivalent to an excess cancer risk of 1 in 100,000 arising from lifetime doses of 0.29 μg MOCA/kg bw/day or 1.56 μg As/kg bw/day.

European Chemicals Agency (2017). Committee for Risk Assessment (RAC) Opinions on 4,4’-methylene-bis-[2-chloroaniline] (MOCA) and on Arsenic acid and its inorganic salts. Adopted 29 May 2017.

https://echa.europa.eu/documents/10162/13641/opinion_moca_en.pdf/35756093-0eb9-e468-2ba2-786ca73c5aaa

https://echa.europa.eu/documents/10162/13641/opinion_arsenic_en.pdf/dd3eb795-108e-5d3a-6847-dddcc021a9dc

 

The above items were taken from the July 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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