Under REACH, read-across is one of the most commonly used approaches to fill data gaps on the effects of substances on human health and the environment, without resorting to laboratory testing on vertebrate animals. Using this concept, the properties of an untested ‘target’ chemical are predicted from experimentally-determined data on a ‘source’ chemical (e.g. a common transformation product or analogous substance) or source chemicals (e.g. categories of substances). Under REACH, it is up to ECHA to decide whether decisions by dossier registrants to use particular read‑across data are justified. The Agency has recently updated its ‘read-across assessment framework’ (RAAF) document, to include the structured approach for this evaluation process for environmental and ecotoxicological endpoints.

European Chemicals Agency (2017). Read-across assessment framework (RAAF). ECHA-17-R-01-EN. March 2017. http://echa.europa.eu/documents/10162/13628/raaf_en.pdf

 

The above items were taken from the March 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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