In November 2009, fifty-three experts from sixteen countries met at BfR to discuss and develop the scientific criteria for regulatory decisions on whether substances should be regarded as having endocrine disrupting properties. Among the issues considered were the importance of extending dosing in toxicity studies to the low dose range, the recognition of critical windows of development, and the need to incorporate further end-points in toxicity testing, such as developmental neurotoxicity and developmental immunotoxicity. In its discussions of the various definitions of negligible exposure (a crucial factor in the decision process), the workshop favoured a more science-based definition over the default value of 0.01 mg/kg food laid down in the European plant protection products regulation (Regulation (EC) No. 1107/2009).

[German Federal Institute for Risk Assessment (BfR). Establishment of assessment and decision criteria in human health risk assessment for substances with endocrine disrupting properties under the EU plant protection product legislation (15 January 2010). Report of the workshop held at BfR on 11-13 November 2009. The document can be obtained from the BfR website (at] {184596}

The above item was taken from the April 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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