Because of the unique properties of manufactured nanomaterials, questions have been raised as to whether current OECD guidelines can be successfully applied in assessing the hazards of this group of chemicals, or whether new methodologies need to be developed. Reassuringly, these issues are currently being considered in depth by the OECD Working Party on Manufactured Nanomaterials, with the result that a manual has now been issued to assist in this area. The publication includes guidance on the toxicological end-points that need to be addressed for the safety assessment of nanomaterials, and the physical-chemical characterisation required for these tiny specks. Preliminary guidance notes have also been issued on sample preparation and dosimetry.

[Organisation for Economic Co-operation and Development. OECD guidance manual for the testing of manufactured nanomaterials: OECD’s sponsorship programme; first revision, ENV/JM/MONO(2009)20/REV, dated 2 June 2010. OECD preliminary guidance notes on sample preparation and dosimetry for the safety testing of manufactured nanomaterials, ENV/JM/MONO(2010)25, dated 31 May 2010. Both documents are available from OECD (at http://www.olis.oecd.org/olis/2009doc.nsf/LinkTo/NT00009C1A/$FILE/JT03284642.PDFn and http://www.olis.oecd.org/olis/2010doc.nsf/LinkTo/NT00002CC2/$FILE/JT03284434.PDF respectively).] {185542-3}

The above item was taken from the August 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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