Skin sensitisation from fragrance ingredients is relatively common and is of concern to fragrance manufacturers. The QRA2 model, developed by the International Fragrance Association, is designed to derive an “acceptable exposure level” for such fragrance allergens, a concentration below which induction of sensitisation is unlikely to occur. The SCCS has evaluated the model and drawn its final conclusions; evidently QRA2 is an improvement on the initial QRA model and “could be a useful methodology not only for risk assessment of fragrance allergens, but potentially also for other cosmetic ingredients”, once the scientific rationales behind several aspects of the methodology are clarified.

Scientific Committee on Consumer Safety (2018). Final opinion on skin sensitisation quantitative risk assessment for fragrance ingredients (QRA2) – Submission 1. SCCS/1589/17. https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_211.pdf

 

The above items were taken from the October 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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