US researchers have suggested that the exposure regimen recommended in current guidelines for rodent cancer bioassays may be too short – typically the animals are exposed for a period commencing several weeks after birth for a maximum of 2 years. The scientists argue that beginning exposure before birth (i.e. in utero) and continuing for a longer treatment duration (of at least 2.5 years) could increase assay sensitivity, avoid false-negative results and strengthen the value and validity of results used in a regulatory context. Case-studies on aspartame, cadmium and toluene are presented as examples (Huff J. et al., Environmental Health Perspectives 2008, 116, 1439). {179642}

The above item is taken from the December 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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