Analysis of twelve publications that presented data on 185 peanut-allergic subjects enabled UK/US scientists to determine, with reasonable precision, doses predicted by selected models to elicit (mild) reactions in 10% of peanut-allergic populations. These ED10 values were in close agreement using three different statistical models, with 95% lower confidence intervals found to be in the range of 6 to 9.2 mg peanut. The investigators considered that the data and risk assessment models they presented could provide the type of information necessary for authorities to establish regulatory thresholds for peanut (Taylor S.L. et al., Food and Chemical Toxicology 2009, 47, 1198; http://dx.doi.org/10.1016/j.fct.2009.02.011). {181995}

The above item was taken from the July 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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