In a joint draft opinion, three European Scientific Committees were of the preliminary view that the principle of the TTC approach in itself was scientifically acceptable for the safety evaluation of chemicals that occurred at low levels, but that its application was dependent on the quality, quantity and relevance of the toxicological data and on a reliable estimation of chemical exposure. Due to the limited exposure information generally available for cosmetic ingredients, and the many possible exposure routes, Committee members considered that the TTC approach was “in general not applicable for intentionally added or formed substances present in cosmetic products” or for impurities in cosmetic ingredients. Other applications of the TTC approach were also discussed.

[Scientific Committee on Consumer Products (SCCP), Scientific Committee on Health and Environmental Risks (SCHER) and Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). Draft opinion on use of the Threshold of Toxicological Concern (TTC) approach for the safety assessment of chemical substances. Preliminary report. Agreed by SCHER, SCCP and SCENIHR on 19 November 2008. Available at http://ec.europa.eu/health/ph_risk/committees/cons_01_en.htm on the internet. Comments on the document are invited by 5 January 2009.] {180040}

The above item is taken from the January 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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