Volume 46, Number 3

March 2007 

TOXICITY PROFILES

Updated BIBRA Toxicity Profile on palladium and its compounds

PART I: WORLD NEWS


INTERNATIONAL

WHO reviews risks of nickel in drinking water
Report of the JECFA 65th meeting
IPCS – skin sensitization risk assessment

EUROPEAN UNION

Guidance on REACH – naming chemicals, and evaluating dossiers and substances
Environmental RARs on four ethylene glycol and propylene glycol ethers
SCCP deliberations on …
… methyl-N-methylanthranilate
… benzophenone-3
… camphor benzalkonium methosulfate
… 2-phenylbenzimidazole-5-sulfonic acid and its salts
… diethylene glycol monoethyl ether
… and diethylene glycol monobutyl ether
SCCP guidance for the testing of cosmetic ingredients
EFSA evaluation of a feed additive containing organic selenium
Low-dose effects of bisphenol A disregarded by EFSA
EFSA assesses safety-in-use of formaldehyde in gelling agents used in food
Polyethylene glycols as coatings for food supplements assessed by EFSA
EFSA evaluates 1,2-benzisothiazolin-3-one as an impurity in saccharin
EFSA guidance on uncertainties in dietary exposure assessment

UNITED KINGDOM

HSE REACH out to the COT
Compendium of chemical hazards issued by Health Protection Agency
Nanomaterial toxicity – COT to consider amending joint Statement
COM February deliberations
IGHRC guidelines on route-to-route extrapolation in risk assessment

UNITED STATES

NTP studies on 4-methylimidazole
Submissions and updates to the EPA HPV Program
Proposed child-specific health criteria for lead – final OEHHA draft
OEHHA evaluates health effects of recycled tyres in playgrounds
Pesticide tolerance petitions filed with the EPA
EPA pesticide tolerances for spiromesifen and thiabendazole
EPA Reregistration Eligibility Decisions
FDA GRAS status letters

OTHER AUTHORITATIVE BODIES

Swedish consensus reports
Revealed: the vinyl chloride industry’s murky past
RIVM fact sheets on …
… changes in blood biochemistry and liver damage
… quantitative risk assessment using the LLNA
… and relevance of increased Leydig cell tumours

PART II: SHORT CUTS

Acrylamide and cancer in man – the evidence weakens
Formaldehyde – a human carcinogen?
Ethylbenzene shows no developmental toxicity in a rat study
Xylenes may enhance ethylbenzene-induced ear effects
Silica and lung cancer – confounding factors
Indium oxide may cause lung damage in workers
Tolerable daily intake for sodium monofluoroacetate – possums beware!
Pesticides further incriminated in the etiology of Parkinson’s disease
Contact sensitivity to the UV filters octyl salicylate and Tinosorb M™?
Allergic contact dermatitis: Laureth 12 and idebenone
Possible estrogenic activity of lavender oil and tea-tree oil in prepubertal boys
Anaphylactic reaction to acid citrate dextrose?
Carcinogenicity of dibromoacetic acid
Bisphenol antioxidants and male reproductive toxicity
Furan study demonstrates no genotoxicity in human cells and mice
FEMA GRAS re-affirmation of aromatic substituted secondary alcohols, ketones
   and related esters
Safety and bioavailablity of ubiquinol for oral use in humans
Meta-analysis finds no clear link between folate and breast cancer
Maternal folic acid supplements and the risk of facial clefts
Folate fortification and vitamin B12 deficiency – good and bad news for the elderly
Vitamins B6 and B12, folic acid supplementation and cognitive function
Vitamins, carotenoids and the risk of precancerous lesions in the mouth
Vitamin supplement combination fails to protect against stomach cancer
Methionine, vitamin B6 and pancreatic cancer
Diet and the risk of venous thromboembolism (VTE)
Children may breathe a little more easily with long-chain polyunsaturated fatty acids
Supplemental calcium and the risk of colorectal adenoma recurrence
Hearty effects of plant sterols
Olives as a cause of contact dermatitis?
Onion and colon cancer
Three coffees a day may keep dementia away
A healthier heart for moderate drinkers?
Dietary oils may affect immune function
Fishy analysis of risks and benefits
Genotoxicity testing – IWGT interpretation and strategies

TRN Homepage Become a Member Our Recent Work