EFSA has evaluated the toxicological risks associated with the presence of TAs (which occur naturally in various plant species) in food and animal feed. Although more than 200 different TAs have been identified, a lack of available data on toxicity and occurrence limited EFSA’s risk assessment to two: (-)-hyoscyamine and (-)-scopolamine.

For these TAs, the critical acute effect was reduced heart rate in human volunteers. Based on this, EFSA derived a group acute reference dose (ARfD) of 0.016 μg/kg bw/day. As these TAs are not bioaccumulative or genotoxic, and “do not exhibit chronic toxicity”, this ARfD was considered protective against the effects of long-term exposure. Dietary exposure could only be reliably assessed for toddlers, for whom intake could exceed the ARfD on 11-18% of exposure days, by up to a factor of seven.

European Food Safety Authority. Panel on Contaminants in the Food Chain (CONTAM). Scientific opinion on tropane alkaloids in food and feed. EFSA Journal 2013, 11(10): 3386.



The above items were taken from the December 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here

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